Some of the sites I visit, in no particular order. Most of which you've probably already heard of. Missing plenty of other good sites. Sorry about that.
By the way, while Xenozoo is sort of "family oriented" a few of the following links are not. So, surf responsibly.
Gunnerkrigg Court
Dresden Codak
Sinfest
Hark, a Vagrant
Skadi and Camp Weedonwantcha
Bad Machinery/Scary Go Round
Octopus Pie
Meek
Vattu, Order of Tales and Rice Boy
Lackadaisy Cats
Harpy Gee
Savage Chickens
Kill 6 Billion Demons
Tuki
Necropolis
Thunderpaw
Gone too soon or something...
Cleopatra in Space (not really gone, but he's busy making graphic novels)
Red's Planet (same, he's making a graphic novel)
Dawn of Time
Museum of Mistakes
Imaginary Monsters
Much the Miller's Son
Ojingogo